Functional and non-functional joining in immunoglobulin light chain genes of a mouse myeloma.
Nature
; 287(5783): 603-7, 1980 Oct 16.
Article
em En
| MEDLINE
| ID: mdl-6776411
ABSTRACT
Leader, variable (V) and joining (J) gene segments, and adjacent regions of two rearranged alleles of the same kappa-chain producing mouse myeloma, comprising approximately 3,200 base pairs, have been sequenced. Sequence comparisons are reported. V-J joining in one of the alleles leads to a reading frame with a stop codon within the J-gene segments. Allelic exclusion is apparently realized in this tumour through the formation of such a non-functional allele.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Sítios de Ligação de Anticorpos
/
Região Variável de Imunoglobulina
/
Proteínas do Mieloma
/
Cadeias kappa de Imunoglobulina
/
Cadeias Leves de Imunoglobulina
Limite:
Animals
Idioma:
En
Revista:
Nature
Ano de publicação:
1980
Tipo de documento:
Article