Increase of urinary putrescine in 3,4-benzopyrene carcinogenesis and its inhibition by putrescine.
Cancer Res
; 38(10): 3509-11, 1978 Oct.
Article
em En
| MEDLINE
| ID: mdl-688235
ABSTRACT
A significant increase in putrescine was noted in the urine of mice with experimental s.c. tumors induced by a single injection of 3,4-benzopyrene solution (2.52 mg of 3,4-benzopyrene in 0.5 ml of tricaprylin). When 10 mg of putrescine were added to the 3,4-benzopyrene solution, the development of tumors was completely inhibited and the increase of urinary putrescine in mice was suppressed simultaneously. Animal weight data of a control group receiving only putrescine indicated that the inhibitory effect of putrescine is not due to its toxicity.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Benzopirenos
/
Putrescina
/
Neoplasias Experimentais
Limite:
Animals
Idioma:
En
Revista:
Cancer Res
Ano de publicação:
1978
Tipo de documento:
Article