[Effect of exogenous prostaglandin E2 on different stages in the formation of a humoral immune response]. / Vliianie ékzogennogo prostaglandina E2 na razlichnye étapy formirovaniia gumoral'nogo immunnogo otveta.

The influence of exogenous prostaglandin E2 on different stages of the immune response to sheep red blood cells was studied in (CBA x C57BL) F1 mouse hybrids. It was shown that prostaglandin E2 in a dose of 10(-6) M given 72 h after antigen challenge increased the number of the plaque-forming cells. Prostaglandin E2 stimulated antibody formation on being injected to mice in doses 10(-6) M--5 . 10(-4) M 24 and 2 h prior to antigen challenge. Prostaglandin E2 enhanced endogenous colony formation when injected to mice 24 and 2 h prior to sublethal irradiation. It is suggested that prostaglandins regulate different stages of the immune response.