Effects of sodium DL-lactate on insulin secretion in anesthetized dogs.
Diabetes
; 29(1): 33-6, 1980 Jan.
Article
em En
| MEDLINE
| ID: mdl-6991314
ABSTRACT
The effect of sodium DL-lactate administration on insulin release in anesthetized dogs has been studied. Eleven mongrel dogs were infused with sodium DL-lactate for 20 min at the rate of 20 mg/kg . min. Lactate infusion produced simultaneous increases in blood glucose and plasma insulin levels in the pancreaticoduodenal vein. To determine whether lactate stimulated insulin secretion directly, sodium DL-lactate was rapidly injected into the pancreatic artery of six dogs; this pulse induced a significant increase in insulin release from pancreatic B-cells, even in the absence of a measurable change in blood glucose. Diazoxide, when infused in six dogs, blocked lactate-induced insulin secretion. These findings indicate that lactate, as do other circulating energy fuels, may play a role in the physiologic control of insulin secretion.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pâncreas
/
Insulina
/
Lactatos
Limite:
Animals
Idioma:
En
Revista:
Diabetes
Ano de publicação:
1980
Tipo de documento:
Article