Comparison of bile acid synthesis determined by isotope dilution versus fecal acidic sterol output in human subjects.
Lipids
; 17(5): 345-8, 1982 May.
Article
em En
| MEDLINE
| ID: mdl-7047967
ABSTRACT
Fecal acidic sterol output has been found to be much lower than bile acid synthesis determined by isotope dilution (J. Lipid Res. 17 17, 1976). Because of this confusing discrepancy, we compared these 2 measurements done simultaneously on 13 occasions in 5 normal volunteers. In contrast to previous findings, bile acid synthesis by the Lindstedt isotope dilution method averaged 16.3% lower than synthesis simultaneously determined by fecal acidic sterol output (95% confidence limit for the difference - 22.2 to -10.4%). When one-sample determinations of bile acid pools were substituted for Lindstedt pools, bile acid synthesis by isotope dilution averaged 5.6% higher than synthesis by fecal acidic sterol output (95% confidence limits -4.9 to 16.1%). These data indicate that the 2 methods yield values in reasonably close agreement with one another. If anything, fecal acidic sterol outputs are slightly higher than synthesis by isotope dilution.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Esteróis
/
Ácidos e Sais Biliares
/
Fezes
Limite:
Humans
Idioma:
En
Revista:
Lipids
Ano de publicação:
1982
Tipo de documento:
Article