Bile acid transformation by the intestinal flora and cholesterol saturation in bile. Effects of Streptococcus faecium administration.
Digestion
; 23(2): 80-8, 1982.
Article
em En
| MEDLINE
| ID: mdl-7095315
ABSTRACT
In 8 normal subjects the daily administration for 30 days of at least 750 X 10(6) Streptococcus faecium, a bacteria producing substances acting against Clostridia and other intestinal microorganisms reduced the cholesterol saturation and the molar percentage of deoxycholic acid (DCA) in bile. The percentage of cholic acid (CA) and chenodeoxycholic acid (DCA) increased significantly in feces, whereas lithocholic acid (LCA) decreased from 49.2 to 40.5%. In vitro fecal samples of subjects taking S. faecium transformed more slowly CA to DCA and CDCA to LCA. Moreover, 7-ketolithocholic seems an intermediate step in the biotransformation of CDCA to LCA. During SF administration, the anaerobic bacteria count of feces decreases, whereas aerobic bacteria increase; the changes of fecal flora may reduce the degradation of primary bile acids influencing the bile acid composition in both the bile and the intestine.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Streptococcus
/
Ácidos e Sais Biliares
/
Colesterol
/
Intestinos
Limite:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Digestion
Ano de publicação:
1982
Tipo de documento:
Article