Search for the biochemical parameters of tumor cell sensitivity and resistance to antimetabolites.
Antibiot Chemother (1971)
; 28: 48-52, 1980.
Article
em En
| MEDLINE
| ID: mdl-7191237
ABSTRACT
The metabolism of murine tumors sensitive and resistant to 6-theopurines and 5-fluorouracil (5-FU) was studied. A positive correlation between the tumor sensitivity to thiopurines, the level of hypoxanthine-guanine-phosphoribosyl transferase and the rates of the antimetabolite incorporation into RNA and DNA was shown. The sensitivity of tumors to 5-FU correlated with the rates of pyrimidine nucleosides and antimetabolite uptake and the time of retention of labeled 5-FU in RNA. The activites of orotate-phosphoribosyl transferase, uridine kinase, the degree of thymidylate synthetase inhibition of 5-FU and ratio of the de novo to salvage pathways of thymidylate biosynthesis are also important.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Experimentais
/
Antimetabólitos Antineoplásicos
Tipo de estudo:
Diagnostic_studies
Limite:
Animals
Idioma:
En
Revista:
Antibiot Chemother (1971)
Ano de publicação:
1980
Tipo de documento:
Article