[Kanamycin sulfate pharmacokinetics in the lymph and blood in complicated acute inflammatory diseases of the abdominal cavity organs]. / Farmakokinetika kanamitsina sul'fata v limfe i krovi pri oslozhnennykh ostrykh vospalitel'nykh zabolevaniiakh organov briushnoi polosti.

ABSTRACT

Pharmacokinetics of kanamycin sulfate in the lymph, blood and urine of 12 patients with acute inflammatory diseases of the organs of the abdominal cavity was studied. The study showed that kanamycin sulfate administered intramuscularly was rapidly absorbed into the lymph and blood reaching the maximum levels within 2 hours of the administration. The therapeutic levels were preserved for at least 8 hours. The concentration of kanamycin in pure lymph by the method of lymphosorption was 20 per cent lower which was connected with the drug adsorption by the sorbents.