Inhibition by cholesterylphosphorylserine of T-cell-mediated immune responses in mice.
Int J Immunopharmacol
; 17(6): 517-21, 1995 Jun.
Article
em En
| MEDLINE
| ID: mdl-7499029
ABSTRACT
The synthetic analogue of phosphatidylserine, cholesterylphosphorylserine (CPHS) inhibits T-cell-mediated immune responses in mice. Tested in cultured mouse spleen cells, CPHS inhibits concanavalin A-induced activation of DNA synthesis (IC50, 3.5 microM). Injected i.p. during the efferent phase, CPHS (25-100 mg/kg) inhibits the manifestations of delayed-type of hypersensitivity. The compound (25 mg/kg i.p., daily) reduces the acute graft-versus-host reaction when given for 5 days to donor mice before the isolation of spleen cells used for the inoculum. These data suggest that the addition of a phosphorylserine group to a steroid ring may produce immunoregulatory compounds.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fosfatidilserinas
/
Fosfosserina
/
Linfócitos T
/
Adjuvantes Imunológicos
/
Colesterol
Limite:
Animals
Idioma:
En
Revista:
Int J Immunopharmacol
Ano de publicação:
1995
Tipo de documento:
Article