Killed poliovirus antigen titration in humans.
Dev Biol Stand
; 41: 119-32, 1978.
Article
em En
| MEDLINE
| ID: mdl-753645
ABSTRACT
To establish the antigen content of a killed poliovirus vaccine sufficiently potent to induce immunity with one or two doses and to establish a reference standard vaccine which has been tested under field conditions, a titration was carried out in infants to determine the amount of each of the three antigenic types of poliovirus vaccine required to induce seroconversion with a single dose. It has been observed that over a critical range of antigen concentration there is an essentially linear relationship between antibody response and quantity of antigen administered. More than 90 percent of the groups studied had detectable antibody after receiving single injections of 80, 8 and 64 D-antigen units of Types I, II and III, respectively. Four-fold less antigen for each of the three types was less effective. The implications of these findings for an efficient immunization procedure are discussed.
Buscar no Google
Coleções:
01-internacional
Contexto em Saúde:
2_ODS3
Base de dados:
MEDLINE
Assunto principal:
Vacina Antipólio de Vírus Inativado
/
Formação de Anticorpos
/
Antígenos Virais
Limite:
Humans
/
Infant
País/Região como assunto:
Africa
Idioma:
En
Revista:
Dev Biol Stand
Ano de publicação:
1978
Tipo de documento:
Article