Bone marrow aplasia and severe skin rash after a single low dose of methotrexate.
Anticancer Drugs
; 6(1): 154-7, 1995 Feb.
Article
em En
| MEDLINE
| ID: mdl-7538828
ABSTRACT
A 64 year old man with recurrent metastatic squamous cell carcinoma of the head and neck developed severe skin rash and bone marrow aplasia 4 and 7 days, respectively, following a single dose of 40 mg/m2 methotrexate (MTX). Skin rash involved regions of the face, lower abdomen, back, buttocks and both upper thighs. Biopsy of the skin rash demonstrated superficial perivascular lymphocytic infiltrate and was consistent with a drug reaction. Peripheral blood count revealed pancytopenia and a bone marrow biopsy was consistent with aplasia. Blood counts returned to normal 6 days after institution of granulocyte colony stimulating factor therapy. In the absence of mucositis or diarrhea, severe dermatologic toxicity following a single low dose of the drug suggests an 'allergic' or acute hypersensitivity reaction to MTX in this patient. Development of an extensive skin rash following a single dose of MTX may be an early warning sign for life-threatening bone marrow aplasia.
Buscar no Google
Coleções:
01-internacional
Contexto em Saúde:
3_ND
Base de dados:
MEDLINE
Assunto principal:
Pancitopenia
/
Carcinoma de Células Escamosas
/
Neoplasias Laríngeas
/
Metotrexato
/
Toxidermias
Limite:
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Anticancer Drugs
Ano de publicação:
1995
Tipo de documento:
Article