The effects of roxatidine on neuromuscular transmission.
In Vivo
; 9(2): 113-5, 1995.
Article
em En
| MEDLINE
| ID: mdl-7548786
ABSTRACT
We have investigated the effects of the H2 receptor antagonist roxatidine on the neuromuscular transmission by using the sciatic nerve-gastrocnemius muscle preparation of the rat in vivo. Roxatidine, administered by i.v. injection, potentiates the neuromuscular blockade induced by d-tubocurarine, pancuronium and aminoglycoside antibiotic, kanamycin. Moreover, the drug alone is capable of producing a blockade on the preparation stimulated at high frequency. The neuromuscular blockade induced by roxatidine is partially reversed by 4-aminopyridine but not by dimaprit.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Piperidinas
/
Antagonistas dos Receptores H2 da Histamina
/
Junção Neuromuscular
Limite:
Animals
Idioma:
En
Revista:
In Vivo
Ano de publicação:
1995
Tipo de documento:
Article