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Effects of Ca-antagonists on oxidative susceptibility of low density lipoprotein (LDL).
Yoshida, H; Ayaori, M; Suzukawa, M; Hosoai, H; Nishiwaki, M; Ishikawa, T; Nakamura, H.
Afiliação
  • Yoshida H; First Department of Internal Medicine, National Defense Medical College, Tokorozawa, Japan.
Hypertens Res ; 18(1): 47-53, 1995 Mar.
Article em En | MEDLINE | ID: mdl-7584910
ABSTRACT
Twelve adults (age 32-61 years) with essential hypertension were recruited from the outpatient clinics of National Defense Medical College hospital to serve as subjects in the present study. They were treated with nilvadipine, a Ca-antagonist, 4 mg b.i.d. for 4 weeks. LDL samples were isolated by ultracentrifugation at the beginning (week 0) and at the end (week 4) of the treatment regimen. The formation of conjugated dienes was measured by incubating 100 micrograms of LDL protein with 2 mumol CuSO4 in 2 ml phosphate buffered saline (PBS). There were no significant differences between lipids levels, composition and anti-oxidant levels of LDL at weeks 0 and 4. The lag time of LDL oxidation was 71.1 +/- 11.3 min at week 0 and 81.3 +/- 13.2 min at week 4 (p < 0.05). In vitro studies of LDL oxidation, evaluated by thiobarbituric acid reactive substances (TBARS) and by agarose electrophoretic mobility, indicated that nilvadipine inhibited the oxidative modification of LDL while amlodipine, used as control, did not. Nilvadipine, a lipophilic Ca-antagonist, significantly prolonged the lag time of conjugated diene formation of LDL by 12.6% but amlodipine, a hydrophilic Ca-antagonist, had no major effect on LDL oxidation. These results suggest that Ca-antagonists are effective for the prevention of atherosclerosis but the effect is dependent upon the lipophilicity of the drugs.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Bloqueadores dos Canais de Cálcio / Nifedipino / Hipertensão / Lipoproteínas LDL Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Hypertens Res Ano de publicação: 1995 Tipo de documento: Article
Buscar no Google
Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Bloqueadores dos Canais de Cálcio / Nifedipino / Hipertensão / Lipoproteínas LDL Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Hypertens Res Ano de publicação: 1995 Tipo de documento: Article