Tubercidin stabilizes microtubules against vinblastine-induced depolymerization, a taxol-like effect.
Cancer Lett
; 96(2): 261-6, 1995 Sep 25.
Article
em En
| MEDLINE
| ID: mdl-7585466
ABSTRACT
A sensitive assay for the detection of microtubule-stabilizing agents [1] was used to screen an extensive collection of cyanobacterial and microalgal extracts. The hydrophilic extract of the cyanobacterium, Plectonema radiosum (UH isolate IC-70-1), exhibited microtubule-stabilizing activity. Bioassay-directed purification of the active compound yielded tubercidin (7-deazaadenosine), a potent cytotoxic nucleoside analog. Further studies revealed that tubercidin protected a population of cellular microtubules against vinblastine-induced depolymerization, a microtubule-stabilizing, taxol-like effect. The microtubule-stabilizing effect of tubercidin is dose dependent and limited by the cytotoxicity of the agent. Tubercidin represents another natural product that interacts with microtubules and is one of the few to cause microtubule stabilization.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Vimblastina
/
Tubercidina
/
Paclitaxel
/
Microtúbulos
Tipo de estudo:
Diagnostic_studies
Limite:
Animals
Idioma:
En
Revista:
Cancer Lett
Ano de publicação:
1995
Tipo de documento:
Article