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VV-hemorphin-7 and LVV-hemorphin-7 released during in vitro peptic hemoglobin hydrolysis are morphinomimetic peptides.
Garreau, I; Zhao, Q; Pejoan, C; Cupo, A; Piot, J M.
Afiliação
  • Garreau I; Laboratoire de Génie Protéique et Cellulaire, Pôle Sciences et Techniques, La Rochelle, France.
Neuropeptides ; 28(4): 243-50, 1995 Apr.
Article em En | MEDLINE | ID: mdl-7596489
Two opioid peptides were generated by in vitro pepsin treatment of bovine hemoglobin. These peptides were identified using a GPI test and purified using HPLC chromatographic techniques. They correspond to fragments 31-40 (LVV-hemorphin-7) and 32-40 (VV-hemorphin-7) of the beta-chain of bovine hemoglobin. Binding experiments strongly confirm that VV-hemorphin-7 and LVV-hemorphin-7 are opioid peptides since they inhibited [3H]naloxone binding to rat brain membranes. Our results indicate that VV-hemorphin-7 and LVV-hemorphin-7 exhibit a lesser potency both in GPI and binding tests. Selectivity and affinity of these purified peptides and synthetic hemorphin-7 for opioid receptors is discussed.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fragmentos de Peptídeos / Hemoglobinas / Receptores Opioides / Morfina Tipo de estudo: Diagnostic_studies Limite: Animals Idioma: En Revista: Neuropeptides Ano de publicação: 1995 Tipo de documento: Article
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fragmentos de Peptídeos / Hemoglobinas / Receptores Opioides / Morfina Tipo de estudo: Diagnostic_studies Limite: Animals Idioma: En Revista: Neuropeptides Ano de publicação: 1995 Tipo de documento: Article