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Two-year biochemical, virological, and histological follow-up in patients with chronic hepatitis C responding in a sustained fashion to interferon alfa-2b treatment.
Reichard, O; Glaumann, H; Frydén, A; Norkrans, G; Schvarcz, R; Sönnerborg, A; Yun, Z B; Weiland, O.
Afiliação
  • Reichard O; Department of Infectious Diseases, Karolinska Institute, Danderyd Hospital, Stockholm, Sweden.
Hepatology ; 21(4): 918-22, 1995 Apr.
Article em En | MEDLINE | ID: mdl-7705800
ABSTRACT
Fourteen patients with chronic hepatitis C who had a sustained response to a 60-week interferon alfa-2b treatment course were followed, biochemically and virologically, 2 years after treatment cessation. Biopsies were repeated in 12 of 14 for histological and virological evaluation at 2-year follow-up. All 14 patients had normal serum alanine transaminase (s-ALT) levels and were negative for hepatitis C virus (HCV) RNA in serum during treatment and at short-term follow-up 6 months post-treatment. At 2-year follow-up, 13 patients still had normal ALT levels (< 0.6 mukat/L for women; < 0.8 mukat/L for men), 1 a near normal level (0.76 mukat/L); all were HCV RNA negative in serum, and 11 of 12 also in the liver. Liver histology improved during treatment and remained stable during the 2-year follow-up. The authors conclude that most sustained responders, who have normal ALT levels and are nonviremic at short-term follow-up 6 months after interferon treatment, will continue to have a durable long-term response without relapse of the viremia.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Interferon-alfa / Hepatite C Tipo de estudo: Observational_studies / Prognostic_studies Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Hepatology Ano de publicação: 1995 Tipo de documento: Article
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Interferon-alfa / Hepatite C Tipo de estudo: Observational_studies / Prognostic_studies Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Hepatology Ano de publicação: 1995 Tipo de documento: Article