Benomyl affects the microtubule cytoskeleton and the glutathione level of mammalian primary cultured hepatocytes.
Toxicol Lett
; 76(2): 135-44, 1995 Mar.
Article
em En
| MEDLINE
| ID: mdl-7725345
ABSTRACT
Rat primary hepatocyte cultures have been used to study the effect of Benomyl alone or in combination with Pirimiphos-methyl. The results presented demonstrate that Benomyl alone is responsible for the microtubular disorganization in both a time- and dose-dependent manner, that the effect is reversible after the agent is removed, and that Benomyl is a potent glutathione-depleting agent. Pirimiphos-methyl, alone or combined with Benomyl had no effect on microtubule organization, but reinforced the decrease in glutathione.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Compostos de Sulfidrila
/
Benomilo
/
Citoesqueleto
/
Glutationa
/
Microtúbulos
Limite:
Animals
Idioma:
En
Revista:
Toxicol Lett
Ano de publicação:
1995
Tipo de documento:
Article