Fetal fibronectin detection for prediction of preterm birth in low risk women.
Br J Obstet Gynaecol
; 102(3): 207-12, 1995 Mar.
Article
em En
| MEDLINE
| ID: mdl-7794844
ABSTRACT
OBJECTIVE:
To evaluate the clinical value of cervical fetal fibronectin detection by a quantitative enzyme-linked immunosorbent assay (ELISA) (PTDcheck, Adeza Biomedical, Sunnyvale, California, USA) as a screening tool for the prediction of preterm contractions and preterm delivery in an unselected population of pregnant women globally considered to be at low risk for preterm delivery (n = 133).DESIGN:
A prospective study in which cervical fetal fibronectin samples were collected at two-week intervals between 26 and 36 weeks of gestation.SETTING:
A regional training hospital.SUBJECTS:
One hundred and thirty-three singleton pregnancies presenting consecutively at an antenatal clinic. MAIN OUTCOMEMEASURE:
Occurrence of preterm contractions and preterm delivery (delivery at < 37 weeks of gestation).RESULTS:
Twenty-four (18%) patients were considered positive for the presence of fetal fibronectin. Overall 15 patients (11%) developed preterm contractions and, despite therapeutic intervention, 10 patients (8%) were delivered preterm. As a predictor for preterm contractions, cervical fetal fibronectin detection had a sensitivity of 47%, a specificity of 86%, a positive predictive value of 29% and a negative predictive value of 93%. As a predictor for preterm delivery, cervical fetal fibronectin detection had a sensitivity of 60%, a specificity of 85% a positive predictive value of 25% and a negative predictive value of 96%.CONCLUSIONS:
Cervical fetal fibronectin determinations at a two-week sampling frequency for prediction of preterm birth in a general obstetric population at low risk for preterm birth has limited clinical value as a routinely performed screening procedure.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Diagnóstico Pré-Natal
/
Colo do Útero
/
Fibronectinas
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Trabalho de Parto Prematuro
Tipo de estudo:
Diagnostic_studies
/
Etiology_studies
/
Observational_studies
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Prognostic_studies
/
Risk_factors_studies
Limite:
Adult
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Female
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Humans
/
Pregnancy
Idioma:
En
Revista:
Br J Obstet Gynaecol
Ano de publicação:
1995
Tipo de documento:
Article