The beneficial effect of BPC 157, a 15 amino acid peptide BPC fragment, on gastric and duodenal lesions induced by restraint stress, cysteamine and 96% ethanol in rats. A comparative study with H2 receptor antagonists, dopamine promotors and gut peptides.
Life Sci
; 54(5): PL63-8, 1994.
Article
em En
| MEDLINE
| ID: mdl-7904712
ABSTRACT
The protection of stomach and duodenum in conjecture with anti-inflammatory effect was demonstrated for a novel 15 amino acid peptide, coded BPC 157, a fragment of the recently discovered gastric juice peptide BPC. BPC 157 (i.p./i.g.) was investigated in rats in comparison with several reference standards in three experimental ulcer models (48 h-restraint stress, subcutaneous cysteamine, intragastrical 96% ethanol ulcer tests) (pre-/co-/post-treatment). Only BPC 157 regimens were consistently effective in all of the tested models. On the other hand, bromocriptine, amantadine, famotidine, cimetidine and somatostatin were ineffective (restraint stress). A dose-dependent protection (cysteamine) and/or partial positive effect (related to treatment conditions) (ethanol), was obtained with glucagon, NPY and secretin whereas CCK/26-30/was not effective. Based on Monastral blue studies BPC 157 beneficial effect appears to be related to a strong endothelial protection.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fragmentos de Peptídeos
/
Úlcera Gástrica
/
Dopaminérgicos
/
Proteínas
/
Cisteamina
/
Etanol
/
Úlcera Duodenal
/
Hormônios Gastrointestinais
/
Antagonistas dos Receptores H2 da Histamina
Tipo de estudo:
Etiology_studies
/
Guideline
Limite:
Animals
Idioma:
En
Revista:
Life Sci
Ano de publicação:
1994
Tipo de documento:
Article