Profound and possibly primary "idiopathic CD4+ T lymphocytopenia" in a patient with fungal infections.
Clin Immunol Immunopathol
; 71(2): 203-7, 1994 May.
Article
em En
| MEDLINE
| ID: mdl-7910124
ABSTRACT
A profound and long-lasting reduction in circulating CD4+ T lymphocytes (< 80/microliters) was found in a 37-year-old man (without known risk factors for HIV infection) presenting with recurrent oral candidiasis who subsequently developed cryptococcal meningitis. Infection with HIV was ruled out by serological and virological studies. In vitro and in vivo cell-mediated immunity was severely impaired. Abnormal phenotypic patterns of both CD4+ and CD8+ cells were consistently observed. A systematic family survey revealed in some of his asymptomatic relatives several immunological abnormalities which may point to a genetically based primary immunodeficiency disorder.
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Coleções:
01-internacional
Contexto em Saúde:
4_TD
Base de dados:
MEDLINE
Assunto principal:
Candidíase Bucal
/
Linfócitos T CD4-Positivos
/
T-Linfocitopenia Idiopática CD4-Positiva
Tipo de estudo:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Adult
/
Humans
/
Male
Idioma:
En
Revista:
Clin Immunol Immunopathol
Ano de publicação:
1994
Tipo de documento:
Article