HIV-associated lymphoma in Africa: an autopsy study in Cote d'Ivoire.
Int J Cancer
; 59(1): 20-4, 1994 Oct 01.
Article
em En
| MEDLINE
| ID: mdl-7927898
ABSTRACT
HIV infection predisposes to the development of non-Hodgkin lymphoma (NHL). The frequency of NHL among HIV-positive adults and children in sub-Saharan Africa is not known. In 1991-1992, a representative autopsy study of HIV infection was performed in Abidjan, Côte d'Ivoire. Of 247 HIV-positive adult (> 14 years) medical patients dying in hospital, 2.8% had NHL, 1.6% with visceral NHL and 1.2% with primary cerebral lymphoma. The estimated crude incidence of NHL among HIV-positive adults in Abidjan was 84/100,000 per year, 10-fold greater than the expected pre-AIDS incidence of NHL but less than the incidence observed among HIV-positive adults in industrialised countries. None of 78 autopsied HIV-positive children (median age = 17 months) had NHL. HIV infection augments the incidence of NHL among adults in Africa, but short survival with advanced HIV disease probably prevents the major increase in HIV-associated NHL seen in industrialised countries. Survival of HIV-positive children in Africa appears too short to permit the significant development of additional NHL; classic Burkitt lymphoma is not an AIDS-associated tumour in Africa.
Palavras-chave
Africa; Africa South Of The Sahara; Autopsy; Biology; Cancer; Clinical Research; Cross Sectional Analysis; Developing Countries; Diseases; Examinations And Diagnoses; French Speaking Africa; Hiv Infections; Immunity; Immunological Effects; Incidence; Ivory Coast; Measurement; Neoplasms; Physiology; Research Report; Viral Diseases; Western Africa
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Linfoma Relacionado a AIDS
Tipo de estudo:
Risk_factors_studies
Limite:
Adolescent
/
Adult
/
Child
/
Child, preschool
/
Female
/
Humans
/
Infant
/
Male
País/Região como assunto:
Africa
Idioma:
En
Revista:
Int J Cancer
Ano de publicação:
1994
Tipo de documento:
Article