Relapse of acute lymphoblastic leukaemia 14 years after presentation: use of molecular techniques to confirm true re-emergence.
Br J Haematol
; 87(2): 437-8, 1994 Jun.
Article
em En
| MEDLINE
| ID: mdl-7947297
ABSTRACT
Late relapse after successful treatment of acute lymphoblastic leukaemia (ALL) in children is well-recognized but rare. It is often uncertain whether this represents a true relapse of the original disease or a second malignancy. We present the case of a patient who relapsed 14 years after the original diagnosis of childhood ALL in whom both the original leukaemic cells and those taken at relapse had an identical T cell receptor gamma (TCRG) gene rearrangement. This analysis confirms that this relapse is a true re-emergence of the patient's original disease. The term 'cure' should be used with caution in childhood ALL, even after long periods in continuous remission.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Rearranjo Gênico da Cadeia gama dos Receptores de Antígenos dos Linfócitos T
/
Leucemia-Linfoma Linfoblástico de Células Precursoras
Tipo de estudo:
Observational_studies
/
Prognostic_studies
Limite:
Child
/
Humans
/
Male
Idioma:
En
Revista:
Br J Haematol
Ano de publicação:
1994
Tipo de documento:
Article