Programmed cell death is affected in the novel mouse mutant Fused toes (Ft).
Development
; 120(9): 2601-7, 1994 Sep.
Article
em En
| MEDLINE
| ID: mdl-7956835
ABSTRACT
We have identified a novel dominant mouse mutant that is characterised by fused toes on the fore limbs and a thymic hyperplasia, in heterozygous animals. Homozygosity of the mutation leads to malformation of the developing brain, lost of the genetic control of left-right asymmetry and to death around day 10 of development. Analysis of both limb development and induction of apoptosis in immature thymocytes in vitro suggest that programmed cell death is affected by the mutation. Since the mutation was caused via a transgene insertion we were able to map it to the D region on mouse chromosome 8. So far, no mutation that affects programmed cell death has been mapped to this chromosome. Thus, this mutation will allow the identification of a novel gene involved in programmed cell death during mammalian development.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Cromossomos
/
Apoptose
/
Extremidades
/
Genes Dominantes
/
Camundongos Mutantes
Limite:
Animals
Idioma:
En
Revista:
Development
Ano de publicação:
1994
Tipo de documento:
Article