Tetracycline compared with mechlorethamine in the treatment of malignant pleural effusions. A randomized trial.
Respir Med
; 88(7): 523-6, 1994 Aug.
Article
em En
| MEDLINE
| ID: mdl-7972977
ABSTRACT
Pleural sclerosis after tube thoracostomy was performed in 40 patients with malignant pleural effusions. The patients were randomly allocated to intrapleural therapy with tetracycline or mechlorethamine. Follow up was obtained on each patient to determine if a symptomatic effusion recurred. The response was classified as a complete or partial response and failure. (Complete response complete lack of reaccumulation of pleural fluid for at least 60 days. Partial response small pleural effusion asymptomatic not requiring further treatment for at least 60 days. Failure all other cases). Tetracycline produced complete or partial control of the effusion in 16 of 20 trials for a duration of 6.1 +/- 4.1 months (range 2-14 months). Mechlorethamine produced control of the effusion in 12 of 20 trials for a duration of 4.4 +/- 1 months (range 2-8 months). These findings indicate that intracavitary tetracycline is a more effective treatment than intracavitary mechlorethamine for the control of neoplastic pleural effusion.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Tetraciclina
/
Escleroterapia
/
Derrame Pleural Maligno
/
Mecloretamina
Tipo de estudo:
Clinical_trials
/
Observational_studies
Limite:
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Respir Med
Ano de publicação:
1994
Tipo de documento:
Article