Response of a promethazine-induced coma to flumazenil.
Ann Emerg Med
; 24(5): 979-82, 1994 Nov.
Article
em En
| MEDLINE
| ID: mdl-7978578
ABSTRACT
We report the first case of a patient in a promethazine-induced coma responding to treatment with flumazenil. A literature search conducted to determine the mechanism behind the antagonism of this overdose showed that promethazine interacts with receptors in the central nervous system. Sedative effects may, in fact, be mediated through the benzodiazepine receptor. We concluded that flumazenil can antagonize the sedative effects of promethazine at these receptors to return the patient to a wakeful state.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Prometazina
/
Flumazenil
/
Coma
Tipo de estudo:
Diagnostic_studies
Limite:
Aged
/
Aged80
/
Humans
/
Male
Idioma:
En
Revista:
Ann Emerg Med
Ano de publicação:
1994
Tipo de documento:
Article