Antiparasitic nitroimidazoles. 8. Derivatives of 2-(4-formylstyryl)-5-nitro-1-vinylimidazole.
J Med Chem
; 18(2): 158-61, 1975 Feb.
Article
em En
| MEDLINE
| ID: mdl-804551
ABSTRACT
A series of 33 thioacetals and hydrazones of 2-(4-formylstyryl)-5-nitro-1-vinylimidazole was prepared and examined for antitrypanosomal properties. The thioacetals were inactive as antitrypanosomal agents but three hydrazones derived from N-aminoguanidine, pyridylacethohydrazide chloride (Girard reagent P), and dimethylaminoacetohydrazide (Girard reagent D) displayed good activity against Trypanosoma rhodesiense.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Tripanossomicidas
/
Nitroimidazóis
Limite:
Animals
Idioma:
En
Revista:
J Med Chem
Ano de publicação:
1975
Tipo de documento:
Article