[Neuro-ophthalmologic complications of disseminated lupus erythematosus]. / Complications neuro-ophtalmologiques du lupus érythémateux disséminé.
Klin Monbl Augenheilkd
; 204(5): 403-6, 1994 May.
Article
em Fr
| MEDLINE
| ID: mdl-8051883
ABSTRACT
BACKGROUND:
Systemic lupus erythematosus (SLE) is a multisystemic inflammatory disease of unknown etiology. Physiopathology includes small vessel occlusion and auto-antibody production. Neuro-ophthalmic complications can be detected in 10-30% of SLE cases. Further, some patients can present with neuro-ophthalmic complications prior to diagnosis of SLE. PATIENTS ANDMETHODS:
We report seven cases of neuro-ophthalmic complications of SLE demonstrating lesions from the retina to the brain. The other possible manifestations of SLE will be reviewed.RESULTS:
Two cases were not yet diagnosed with SLE when neuro-ophthalmic disease occurred. Anti-double stranded DNA antibodies were detected at a very high titer, suggesting SLE, later confirmed by rheumatologists.CONCLUSIONS:
Ophthalmologists should be aware of the unusual patient presenting with a neuroophthalmic disorder prior to the diagnosis of SLE. In such cases, autoantibodies should be sought. Antinuclear antibodies are very sensitive but non specific for SLE. Anti-double stranded DNA antibodies are specific for SLE and elevated titer should raise the suspicion of undiagnosed SLE.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Doenças Retinianas
/
Doenças do Nervo Óptico
/
Baixa Visão
/
Lúpus Eritematoso Sistêmico
Limite:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
Fr
Revista:
Klin Monbl Augenheilkd
Ano de publicação:
1994
Tipo de documento:
Article