Carcinogens and dicumarol: opposite effects on rat liver NAD(P)H dehydrogenation.
Enzyme
; 23(4): 217-24, 1978.
Article
em En
| MEDLINE
| ID: mdl-81130
ABSTRACT
The carcinogens, N-acetyl-aminofluorene, 7,12-dimethylbenzanthracene, 3,4-benzpyrene and 3-methylcholanthrene, increase the activity of the soluble enzyme D-T-diaphorase. This action is observed 24 h after the administration of these chemicals to rats. Dicumarol blocks this effect. Dicumarol does not inhibit the increase in activity of the microsomal aryl hydrocarbon hydroxylase system as elicited by 3,4-benz(a)pyrene and 3-methylcholanthrene. The functional significance of these findings and the possible role of cytosolic enzymic changes in chemical toxicity are discussed.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Quinona Redutases
/
Dicumarol
/
Carcinógenos
/
NADH NADPH Oxirredutases
Limite:
Animals
Idioma:
En
Revista:
Enzyme
Ano de publicação:
1978
Tipo de documento:
Article