[Cytogenetic and cytomorphologic parallels of human lymphocytes]. / Tsitogeneticheskie i tsitomorfometricheskie paralleli limfotsitov cheloveka.

ABSTRACT

Association frequency of human acrocentric chromosomes is the function of the period of interphase of cells and the activity of their proliferation. This characteristic, therefore, can be used for the analysis of the dynamics of cellular populations. Variations in the classes of frequencies of lymphocytes with different associating centric chromosomes were compared with the frequency of different classes. The dynamics of the classes of lymphocytes without associations and with two associating acrocentrics correlated in force and direction with different classes with the diameter up to 0.5 mcm, the fact witnessing their functional unity. They make up a pool of newly-formed activated populations of lymphocytes, whose character of dynamics can be used for analysing proliferative and migrational activities of lymphocytes in the initial periods of immunogenesis in lymphoid organs. The increase in the number of associations in long-circulating lymphocytes was followed by an adequate increase in cellular sizes, the latter being the reflection of their following immunological functions. Changes in frequencies of associative and different classes in blood and pleural exudate of patients took place in accordance with the pathogenesis of a concrete illness as well as the character of the factors affecting the body.