Long-range cis preference in DNA homology search over the length of a Drosophila chromosome.
Science
; 263(5153): 1623-5, 1994 Mar 18.
Article
em En
| MEDLINE
| ID: mdl-8128250
ABSTRACT
P element-induced chromosome breakage on the X chromosome of Drosophila melanogaster was repaired six times more frequently when a homologous template was located anywhere on the X chromosome rather than on an autosome. Cis-trans comparisons confirmed that recombinational repair was more frequent when the interacting sequences were physically connected. These results suggest that the search for homology between the broken ends and a matching template sequence occurs preferentially in the cis configuration. This cis advantage operates over more than 15 megabases of DNA.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
DNA
/
Homologia de Sequência do Ácido Nucleico
/
Cromossomos
/
Reparo do DNA
/
Drosophila melanogaster
/
Conversão Gênica
Aspecto:
Patient_preference
Limite:
Animals
Idioma:
En
Revista:
Science
Ano de publicação:
1994
Tipo de documento:
Article