[The effect of chenophalk on the liver function of intact animals and in experimental hepatitis]. / Vliianie khenofal'ka na sostoianie pecheni u intaktnykh zhivotnykh i pri éksperimental'nom gepatite.
Eksp Klin Farmakol
; 57(1): 35-8, 1994.
Article
em Ru
| MEDLINE
| ID: mdl-8142861
ABSTRACT
Chenophalk (chenodeoxycholeic acid) was given to Wistar rats, including intact animals and those with chronic toxic hepatitis, in daily oral dose of 15 mg/kg body weight during 11 days. Chronic toxic hepatitis was induced by 7 subcutaneous injections of carbon tetrachloride (0.3 ml of 50% oil solution per kg body weight) each three days. Chenophalk was shown to impair bile crystallization. It enhanced demethylase activity, elevated the levels of cytochromes P-450 and b5 in the liver microsomal fraction, and decreased lipid peroxidation just after injection. The agent normalized oxygen tension in the liver tissue, which had been reduced by carbon tetrachloride. Chenophalk caused disturbances in the structure of the liver and in microcirculation early after injection, showing a tendency to normalize the histostructure of the liver.
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Coleções:
01-internacional
Contexto em Saúde:
2_ODS3
Base de dados:
MEDLINE
Assunto principal:
Ácido Quenodesoxicólico
/
Doença Hepática Induzida por Substâncias e Drogas
/
Fígado
Tipo de estudo:
Etiology_studies
Limite:
Animals
Idioma:
Ru
Revista:
Eksp Klin Farmakol
Ano de publicação:
1994
Tipo de documento:
Article