[The ultrastructural changes in guinea pig organs during the serial passage of the Ebola virus]. / Ul'trastrukturnye izmeneniia v organakh morskikh svinok pri posledovatel'nom passirovanii virusa Ebola.

ABSTRACT

Morphological study of internal organs of guinea pigs inoculated with Ebola virus at 2-8 passages was carried out. In the course of these passages the number of infected cells and virus particles in the organs was shown to increase, and the destructive changes in organs became more pronounced. In the 1st-3rd passages Ebola virus replication was observed in macrophagal cells only but beginning from the 4th passage of virus reproduction was found also in hepatocytes, spongiocytes, and fibroblasts.