Peculiar T-cell signaling does not preclude positive selection in the diabetes-prone BB rat.
Diabetes
; 43(1): 47-52, 1994 Jan.
Article
em En
| MEDLINE
| ID: mdl-8262316
ABSTRACT
Various studies have provided evidence that peripheral T-cells from the diabetes-prone BB-DP rat are abnormal in function and cell surface phenotype. These characteristics have often been interpreted as indicators of immaturity and/or short life span. In this study, we describe a CD4-dependent signaling abnormality in BB-DP peripheral T-cells. In spite of the fact that CD4 plays a critical role in thymocyte development, the abnormal signaling does not appear to influence thymocyte development at the stage when the T-cell receptor is rearranged and the recombinase enzymes RAG-1 and RAG-2 transcripts are downregulated. Therefore, if a maturation defect leading to the seeding of the periphery with immature T-cells occurs in the BB-DP rat, it does not preclude the initial selection of the self major histocompatibility complex-restricted T-cell repertoire.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ratos Endogâmicos BB
/
Linfócitos T
/
Proteínas de Homeodomínio
/
Integrases
/
Diabetes Mellitus Tipo 1
/
Proteínas de Ligação a DNA
Limite:
Animals
Idioma:
En
Revista:
Diabetes
Ano de publicação:
1994
Tipo de documento:
Article