Simulation studies of multiple dipole neuromagnetic source localization: model order and limits of source resolution.
IEEE Trans Biomed Eng
; 40(6): 529-40, 1993 Jun.
Article
em En
| MEDLINE
| ID: mdl-8262534
ABSTRACT
Numerical simulation studies were performed using a multiple dipole source model and a spherical approximation of the head to examine how the resolution of simultaneously active neuromagnetic sources depends upon 1) source modeling assumptions (i.e., number of assumed dipoles); 2) actual source parameters (e.g., location, orientation, and moment); and 3) measurement errors. Forward calculations were conducted for a series of source configurations in which the number of dipoles, specific dipole parameters, and noise levels were systematically varied. Simulated noisy field distributions were fit by multiple dipole models of increasing model order (1, 2, ..., 6 and alternative statistical approaches (i.e., percent of variance, reduced chi-square, and F-ratio) were compared for their effectiveness in determining adequate model order. Limits of spatial resolution were established for a variety of multi-source configurations and noise conditions. Implications for the analysis of empirical data are discussed.
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Coleções:
01-internacional
Contexto em Saúde:
1_ASSA2030
Base de dados:
MEDLINE
Assunto principal:
Magnetoencefalografia
/
Modelos Estatísticos
/
Modelos Biológicos
Tipo de estudo:
Health_economic_evaluation
/
Risk_factors_studies
Idioma:
En
Revista:
IEEE Trans Biomed Eng
Ano de publicação:
1993
Tipo de documento:
Article