Behavioural and biochemical evidence that glucocorticoids are not involved in DOI-elicited 5-HT2 receptor down-regulation.
Eur J Pharmacol
; 249(1): 117-20, 1993 Nov 02.
Article
em En
| MEDLINE
| ID: mdl-8282013
ABSTRACT
Numerous studies have brought evidence for reciprocal relationships between glucocorticoids and 5-HT2 receptors; however, whether glucocorticoids affect 5-HT2 receptor regulation is still unknown. Herein, we have analyzed whether 5-HT2 receptor down-regulation following repeated administration of the 5-HT2/5-HT1C receptor agonist 1-(4-iodo-2,5-dimethoxyphenyl)-2-aminopropane (DOI) is affected by glucocorticoid removal. Compared with sham surgery, adrenalectomy (11-15 days beforehand) did not affect either frontal cortex [3H]ketanserin binding nor the number of head shakes elicited by a single administration of DOI (2.5 mg/kg s.c.). Pretreatment with DOI (2.5 mg/kg s.c. x 4 in 48 h) decreased to similar extents the head shake response to DOI injection in sham (-88%) and adrenalectomised (-95%) rats. Confirmingly, this paradigm was found to diminish the Bmax for [3H]ketanserin binding in sham and adrenalectomised rats by 64% and 46%, respectively. From these data, it is concluded that glucocorticoid removal does not alter 5-HT2 receptor binding and function nor does it affect 5-HT2 receptor down-regulation.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Comportamento Animal
/
Receptores de Serotonina
/
Agonistas do Receptor de Serotonina
/
Glucocorticoides
/
Anfetaminas
Limite:
Animals
Idioma:
En
Revista:
Eur J Pharmacol
Ano de publicação:
1993
Tipo de documento:
Article