Vasopressin and oxytocin production by non-neuroendocrine lung carcinomas: an apparent low incidence of gene expression.
Cancer Lett
; 75(2): 79-85, 1993 Dec 10.
Article
em En
| MEDLINE
| ID: mdl-8293425
ABSTRACT
In previous studies we have demonstrated the high incidence of vasopressin gene expression as a characteristic feature of small-cell carcinoma of the lung. In the present study we examined expression of this gene in non-neuroendocrine tumors to determine if vasopressin production is a common feature of all lung tumors. We carried out the immunohistochemical evaluation of 22 non-neuroendocrine tumors (12 adenocarcinomas and 10 squamous-cell carcinomas) with antibodies to vasopressin, to oxytocin, and to their related neurophysins. The antibody preparations directed against vasopressin, oxytocin, or oxytocin-associated human neurophysin did not react with any of the tumors examined. Of two monoclonal antibodies to vasopressin-associated human neurophysin used, one did not react with any of the tumors, while the other stained neoplastic cells in only one adenocarcinoma and one squamous-cell carcinoma. These findings, taken with previous reports, indicate that among lung carcinomas, a high incidence of vasopressin/oxytocin gene expression is confined to neuroendocrine tumors.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neurofisinas
/
Ocitocina
/
Vasopressinas
/
Neoplasias Pulmonares
Tipo de estudo:
Incidence_studies
/
Risk_factors_studies
Limite:
Humans
Idioma:
En
Revista:
Cancer Lett
Ano de publicação:
1993
Tipo de documento:
Article