[Distribution of harringtonine positively and negatively charged liposome in rat tissues].
Zhongguo Yao Li Xue Bao
; 14(2): 176-8, 1993 Mar.
Article
em Zh
| MEDLINE
| ID: mdl-8352016
ABSTRACT
Distribution of harringtonine positively and negatively charged liposome (HL(+), HL(-)) and harringtonine free drug (FH) in rat tissues were measured by HPLC. Their LD50 in mice were compared. The results showed that distribution of HL(+), HL(-), In vivo may be changed, that the amount of HL(+), HL(-) was increased in the liver, lung, and spleen and in these tissues it was 2-30-fold higher than that of HF after iv 2 h. HL(+), HL(-) may aid to permeate through the blood-brain, blood-testicle barrier, and to reduce acute lethal toxicity. Areas under the time curve of HL(+), HL(-) in brain and testis within 2 h were 2-4.5 times as much as those of HF. There were significant differences in the fate between negatively and positively charged liposomes in vivo.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Harringtoninas
Limite:
Animals
Idioma:
Zh
Revista:
Zhongguo Yao Li Xue Bao
Ano de publicação:
1993
Tipo de documento:
Article