Subchronic toxicity study of methyl hesperidin in mice.
Toxicol Lett
; 69(1): 37-44, 1993 Jul.
Article
em En
| MEDLINE
| ID: mdl-8356566
ABSTRACT
A subchronic toxicity study of methyl hesperidin was performed using B6C3F1 mice. The flavonoid was administered to groups of ten males and ten females in dietary levels of 0, 0.3, 0.6, 1.25, 2.5 and 5.0% for 13 weeks. No significant treatment-related differences were found in data for body weights, food and water consumption, hematology, clinical chemistry and organ weights. Furthermore, no effects of treatment were observed on gross and histopathological examination of the major organs. The present experiment thus demonstrated that methyl hesperidin exerts no obvious toxic effects in mice of either sex when administered at a level as high as 5.0% in the diet.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Hesperidina
Limite:
Animals
Idioma:
En
Revista:
Toxicol Lett
Ano de publicação:
1993
Tipo de documento:
Article