Synthesis, antifertility activity, and protein binding affinity of 7(8 leads to 11 alpha)abeo steroids.
J Med Chem
; 20(4): 547-51, 1977 Apr.
Article
em En
| MEDLINE
| ID: mdl-850240
ABSTRACT
A series of 7(8 leads to 11 alpha)abeo steroids was synthesized by a modification of the previously described total synthesis of this class of compounds and evaluated for biological activity. In general, there was a marked reduction in the relative binding affinities of these compounds for the rabbit uterus estrogen and progestin receptor proteins. None of the compounds which were subjected to uterotropic, antiuterotropic, postcoital, progestational, antiprogestational, or antiandrogenic assays showed any significant activity.
ABSTRACT
PIP Synthesis, antifertility activity, and protein binding afinity of 7(8 to 11alph) abeo-estranes and -pregnanes are described. There was a marked reduction in the relative binding affinities of these compounds for the rabbit uterus estrogen and progestin receptor proteins. None of the compounds subjected to uterotropic, antiuterotropic, postcoital, progestational, antiprogestational, or antiandrogenic assays revealed any marked activity.
Palavras-chave
Animals, Laboratory; Biology; Clinical Research; Contraception; Contraception Research; Endocrine System; Estrogens--analysis; Examinations And Diagnoses; Family Planning; Genitalia; Genitalia, Female; Hormone Receptors; Hormones; In Vitro; Laboratory Examinations And Diagnoses; Laboratory Procedures; Membrane Proteins; Physiology; Progestational Hormones; Progesterone--analysis; Research Methodology; Urogenital System; Uterus
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Esteroides
/
Fertilidade
Limite:
Animals
Idioma:
En
Revista:
J Med Chem
Ano de publicação:
1977
Tipo de documento:
Article