[Parkinsonism induced by sodium valproate]. / Síndrome parkinsoniano inducido por valproato sódico.

ABSTRACT

Parkinsonism is a rare side effect of treatment with sodium valproate. We report 2 elderly women who developed parkinsonian syndrome several years after starting valproate therapy, and in whom symptoms disappeared when treatment was withdrawn. These cases, along with others in the literature, may support experimental evidence for the importance of GABAergic modulation in motor control.