The use of prothrombin fragment F1+2 to monitor the effect of oral anticoagulation.
J Heart Valve Dis
; 4(2): 138-40, 1995 Mar.
Article
em En
| MEDLINE
| ID: mdl-8556173
ABSTRACT
In comparison to a control group of 47 healthy, non-anticoagulated persons, 164 patients under stable oral anticoagulation therapy showed significant reduction in the plasma level of the prothrombin fragment F1+2 (p < 0.0005). Even with low intensity anticoagulation (INR < 2.0), F1+2 levels were reduced to within the normal range (0.32 - 1.2 nM/l) in all patients. The reduction in the plasma level of prothrombin fragment F1+2 is directly dependent on the intensity of oral anticoagulation therapy and provides a means of monitoring the anticoagulation effect achieved. Clinical studies are required to assess the practicality of using F1+2 for monitoring anticoagulation and in particular to assess the usefulness of low levels in predicting bleeding risk and high levels in predicting thrombotic risk during treatment.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fragmentos de Peptídeos
/
Femprocumona
/
Tromboembolia
/
Protrombina
/
Anticoagulantes
Tipo de estudo:
Clinical_trials
/
Prognostic_studies
Limite:
Adult
/
Aged
/
Aged80
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Humans
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Middle aged
Idioma:
En
Revista:
J Heart Valve Dis
Ano de publicação:
1995
Tipo de documento:
Article