Association of cyclin-dependent kinase-4 and cyclin D1 in neonatal beta cells after mitogenic stimulation by lysophosphatidic acid.
Biochem Biophys Res Commun
; 218(1): 132-6, 1996 Jan 05.
Article
em En
| MEDLINE
| ID: mdl-8573118
ABSTRACT
Neonatal pancreatic islet beta cells retain a mitogenic capacity in response to growth factors. In this study an increased incorporation of 5-bromo-2'-deoxyuridine in response to oleoyl-lysophosphatidic acid is preceded by a GTP-dependent increase in phosphorylation of the extracellular signal-related kinase, ERK1. The presence of cyclin-dependent kinase-4 and an association with a catalytic partner cyclin D1, a process by which the progression through the cell cycle is regulated in other cell types, was shown to follow this. The mechanisms linking ERK1 phosphorylation and activation of cell cycle progression are not known. Investigation of this process in neonatal beta cells may provide a common pathway for the early response to growth factors and the conditions required for an increase in beta cell mass by proliferation.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Lisofosfolipídeos
/
Ilhotas Pancreáticas
/
Proteínas Proto-Oncogênicas
/
Proteínas Oncogênicas
/
Ciclinas
/
Proteínas Quinases Dependentes de Cálcio-Calmodulina
/
Quinases Ciclina-Dependentes
/
Proteínas Quinases Ativadas por Mitógeno
/
Mitógenos
Tipo de estudo:
Risk_factors_studies
Limite:
Animals
Idioma:
En
Revista:
Biochem Biophys Res Commun
Ano de publicação:
1996
Tipo de documento:
Article