Temporal differences in praziquantel- and oxamniquine-induced tegumental damage to adult Schistosoma mansoni: implications for drug-antibody synergy.
Parasitology
; 112 ( Pt 1): 47-58, 1996 Jan.
Article
em En
| MEDLINE
| ID: mdl-8587801
ABSTRACT
A temporal study of the effects on the tegument of Schistosoma mansoni adult worm following in vivo praziquantel and oxamniquine treatment was performed. Drug-induced damage to the tegument, exposure of surface antigens and attachment of host antibody occurred rapidly, within 1 h, following praziquantel treatment. Oxamniquine-treated worms required 4-8 days for these effects to be apparent. The 2 drugs differed in the degree and sites of damage on the worm surface. The administration of 2 different polyspecific rabbit sera with drug significantly increased the efficacy of praziquantel when administered with the drug, but not when given 6-9 days after drug treatment. In contrast, only 1 serum was synergistic with oxamniquine when administered with drug and both sera were synergistic when given 6-9 days after drug treatment. The effect of immune killing of drug-treated worms is discussed.
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Coleções:
01-internacional
Contexto em Saúde:
3_ND
Base de dados:
MEDLINE
Assunto principal:
Oxamniquine
/
Praziquantel
/
Schistosoma mansoni
/
Esquistossomicidas
/
Esquistossomose mansoni
/
Anticorpos Anti-Helmínticos
/
Imunização Passiva
Limite:
Animals
Idioma:
En
Revista:
Parasitology
Ano de publicação:
1996
Tipo de documento:
Article