Relationships between conformational behaviour and binding affinity towards beta 1 and beta 2 adrenoceptors of some chiral phenoxypropanolamines with bulky N-substituents.
Farmaco
; 50(10): 643-58, 1995 Oct.
Article
em En
| MEDLINE
| ID: mdl-8590572
ABSTRACT
The optical isomers of a series of phenoxypropanolamine compounds with N-substituents bulkier than isopropyl have been synthesized, and their binding affinity towards beta 1 and beta 2-adrenoceptors has been determined. A computational study, including a Molecular Dynamics (MD) simulation and quenching in water and a GRID analysis provided some useful suggestions for possible interpretation patterns for the different affinity exhibited by the compounds studied.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Éteres Fenílicos
/
Propanolaminas
/
Receptores Adrenérgicos beta 2
/
Receptores Adrenérgicos beta 1
Idioma:
En
Revista:
Farmaco
Ano de publicação:
1995
Tipo de documento:
Article