Methylprednisolone and isoproterenol inhibit airway smooth muscle proliferation by separate and additive mechanisms.
Life Sci
; 59(1): PL9-14, 1996.
Article
em En
| MEDLINE
| ID: mdl-8684264
ABSTRACT
To determine whether glucocorticoids and beta-adrenoceptor agonists act independently to inhibit airway smooth muscle (ASM) proliferation, the present study investigated the effects of methylprednisolone (MP) and isoproterenol (ISO) alone and in combination on leukotriene D4-induced ASM proliferation. MP and ISO had no effect on unstimulated ASM cell growth. In contrast, MP and ISO demonstrated dose-dependent inhibition of LTD4-induced proliferation, and the inhibitory effect was additive for combinations of MP and ISO. The competitive cAMP receptor antagonist, Rp-cAMPS, ablated the ISO-induced inhibition but had no affect on the inhibitory response to MP. In cells exposed to both ISO and MP, Rp-cAMPS attenuated the growth inhibition to levels achieved by MP alone. Accordingly, these findings demonstrate that glucocorticoids and beta-adrenergic agonists inhibit LTD4-induced ASM proliferation, and that their inhibitory effects are mediated by different signaling pathways.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Sistema Respiratório
/
Metilprednisolona
/
Contagem de Células
/
Isoproterenol
/
Músculo Liso
Limite:
Animals
Idioma:
En
Revista:
Life Sci
Ano de publicação:
1996
Tipo de documento:
Article