Effect of aluminum on hematopoiesis after intraperitoneal exposure in rats.
Ecotoxicol Environ Saf
; 33(3): 201-6, 1996 Apr.
Article
em En
| MEDLINE
| ID: mdl-8727512
ABSTRACT
The experiments were performed on female Wistar rats that received aluminum chloride every day intraperitoneally, 4 mg Al/kg for 3 weeks. In the blood selected morphological factors and delta-aminolevulinic acid dehydratase activity (ALA-D) were investigated. In the kidney and liver ALA-D, delta-aminolevulinic acid synthase (ALA-S), and heme oxygenase activity were also determined. After aluminum chloride administration the most sensitive indicator was an increase of heme oxygenase activity in the liver and a decrease in iron levels in the serum of rats. Aluminum also increased ALA-S activity in the kidney and liver of rats. No changes of ALA-D activity in the liver, the kidney, and the blood were observed. The decreasing of hemoglobin, hematocrit, mean corpuscular hemoglobin mass, and mean corpuscular hemoglobin concentration was noted after 3 weeks of exposure.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Cloretos
/
Compostos de Alumínio
/
Hematopoese
/
Rim
/
Fígado
Limite:
Animals
Idioma:
En
Revista:
Ecotoxicol Environ Saf
Ano de publicação:
1996
Tipo de documento:
Article