mdm-2 oncoprotein expression associated with deletion of the long arm of chromosome 12 in a case of mantle cell lymphoma with blastoid transformation [corrected].
Mod Pathol
; 9(4): 355-9, 1996 Apr.
Article
em En
| MEDLINE
| ID: mdl-8729971
ABSTRACT
We report a unique case of mantle cell lymphoma in blastoid transformation associated with deletion of the long arm of chromosome 12 and with 90 kDa mdm-2 protein overexpression. Neither the mantle cells nor their blastoid counterparts expressed p53 gene product by immunohistochemical analysis. This seems to be the first reported case of this subtype of lymphoma associated with these specific cytogenetic and molecular genetic abnormalities.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Linfoma não Hodgkin
/
Proteínas Nucleares
/
Transformação Celular Neoplásica
/
Proteínas Proto-Oncogênicas
/
Proteínas de Neoplasias
Tipo de estudo:
Risk_factors_studies
Limite:
Aged
/
Humans
/
Male
Idioma:
En
Revista:
Mod Pathol
Ano de publicação:
1996
Tipo de documento:
Article