Novel azacyclic ureas that are potent inhibitors of HIV-1 protease.
Biochem Biophys Res Commun
; 225(2): 436-40, 1996 Aug 14.
Article
em En
| MEDLINE
| ID: mdl-8753780
ABSTRACT
A series of novel, azacyclic ureas which are highly potent inhibitors of the HIV-1 protease (IC50 = 4.1 to < 0.5 nM) were synthesized. Aqueous solubilities of this series of compounds were improved by incorporating polar functional groups at the P1' P2 and P2' positions. These compounds also possess good anti-viral activity by inhibition of the cytopathic effect of HIV-13B in MT-4 cells in vitro.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ureia
/
HIV-1
/
Inibidores da Protease de HIV
Limite:
Animals
/
Humans
/
Male
Idioma:
En
Revista:
Biochem Biophys Res Commun
Ano de publicação:
1996
Tipo de documento:
Article