Pathogenesis of osteopetrosis in the microphthalmic mouse: reduced bone resorption.
Am J Anat
; 149(2): 269-75, 1977 Jun.
Article
em En
| MEDLINE
| ID: mdl-879046
ABSTRACT
Bone resorption, stimulated by injection of parathyroid extract, was measured in vivo in microphthalmic mice as the rate of release of 3H from bone after incorporation of 3H-proline. Bone resorption in these mice, which inherit osteopetrosis, was less than 10% of the in normal litermates. Autoradiography confirmed the reduction in removal of radioactive bone matrix and in bone growth in microphthalmic mice. The ability of these mice to raise the serum calcium concentration in response to PTE was also reduced. These results, that bone resorption is reduced in microphthalmic mice, are discussed in relation to the pathogenesis and cure of the disease.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Osteopetrose
/
Reabsorção Óssea
/
Microftalmia
Tipo de estudo:
Etiology_studies
Limite:
Animals
Idioma:
En
Revista:
Am J Anat
Ano de publicação:
1977
Tipo de documento:
Article