Conservation of dorsal-ventral patterning in arthropods and chordates.
Curr Opin Genet Dev
; 6(4): 424-31, 1996 Aug.
Article
em En
| MEDLINE
| ID: mdl-8791529
ABSTRACT
Dorsal-ventral patterning within the ectodermal and mesodermal germ layers of Drosophila and Xenopus embryos is specified by a system of genes that has been conserved over 500 million years of evolution. In both organisms, the activity of the TGF-beta family member DPP/BMP4 is antagonized by SOG/CHORDIN. A second Xenopus gene, noggin, has a similar biological activity to chordin. Analysis of the action of these genes indicate that Spemann's organizer promotes dorsal cell fates in Xenopus by antagonizing a ventralizing signal encoded by the Bmp4 gene.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Xenopus
/
Glicoproteínas
/
Proteínas de Drosophila
/
Peptídeos e Proteínas de Sinalização Intercelular
/
Drosophila
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Curr Opin Genet Dev
Ano de publicação:
1996
Tipo de documento:
Article